The Enrico Fermi Research Center - CREF promotes original and high-impact lines of research, based on physical methods, but with a strong interdisciplinary character and in relation to the main problems of the modern knowledge society.
The CREF was born with a dual soul: a research centre and a historical museum. Its aim is to preserve and disseminate the memory of Enrico Fermi and to promote the dissemination and communication of scientific culture.
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maria.guidi@cref.it
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I obtained my MSc degree in Physics from the Faculty of Physics and Life Sciences at Copenhagen University in 2013 with a thesis entitled “Scale selection in fracture patterns: A case study in columnar joints”.I then moved to Leipzig, Germany, where I pursued my PhD under the supervision of Prof. Dr. Harald E. Möller and Dr. Laurentius Huber at the Max Planck Institute for Human Cognitive and Brain Sciences.
My doctoral thesis, entitled “Physiological modulators of the BOLD response in the human primary motor cortex”, focused on methods for high-resolution imaging of the functional response using a state-of-the-art Siemens Magnetom 7T MR scanner. An important outcome of my doctoral work was the extraction of a layer-dependent profile of changes in cerebral metabolic rate of oxygen consumption (CMRO2) during a finger-tapping task.Currently my research focuses on the separation of the neuronal component from the vascular component in the BOLD response and on their characterization in terms of frequency content, dynamic features and spatial localization. To this end I combine various techniques including calibrated fMRI, vascular-space occupancy (VASO), arterial spin labeling (ASL), cerebrovascular reactivity mapping, and connectivity.
Since May 2025 I work as a researcher (contrattista di ricerca) in the research group “Neuroscience and Quantitative Neuroimaging” (Dott. Federico Giove) and I collaborate with Fondazione Santa Lucia IRCCS.