The CREF Laboratories are infrastructures located in the basement of the historical Panisperna building. They and are active in the following experimental research activities: Cultural Heritage, Computational Photonics and the Extreme Energy Events (EEE) project. Over the last 3 years, the laboratories have been set up and are now fully operational and productive. The dedicated areas are approximately 200 m2, are open to the public and the staff are actively involved in specific Third Mission activities with students and the general public. The laboratories are equipped with basic instrumentation for the experimental activities described below, as well as IT infrastructure for data processing and storage.